Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19065281 | 0.84 | ALDH1A1 (0.46) | KDM4EHPGDMIFALDH1A1SMN1; SMN2 | |
| SCHEMBL8825211 | 0.81 | CYP4F2 (0.49) | KDM4EHPGDALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL18981803 | 0.80 | HPGD (0.44) | KDM4EHPGDMIFALDH1A1SMN1; SMN2 | |
| SCHEMBL8825405 | 0.79 | HPGD (0.50) | KDM4EHPGDALDH1A1HSD17B10CA1 | |
| SCHEMBL8825534 | 0.79 | KDM4E (0.44) | KDM4EHPGDMIFALDH1A1SMN1; SMN2 | |
| SCHEMBL8825306 | 0.78 | KDM4E (0.48) | KDM4EHPGDALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL8825252 | 0.75 | KDM4E (0.46) | KDM4EHPGDALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL9176305 | 0.74 | CYP4F2 (0.47) | KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL24259216 | 0.74 | KMT2A (0.47) | KDM4EHPGDMIFALDH1A1TSHR | |
| SCHEMBL9146179 | 0.72 | HPGD (0.45) | KDM4EHPGDMIFALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624943-A | Pyridine compounds which are useful as leukotriene-B4 -antagonists | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-04-29 | — | — | US | disclosed |
| EP-0651745-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B 4? ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002464-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B4 ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-02-03 | — | — | WO | disclosed |