Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.56 |
| ▸ | CTSD | P07339 | 8/20 | 0.46 |
| ▸ | METAP2 | P50579 | 3/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14420289 | 0.88 | REN (0.60) | RENCTSDMETAP2CPB2METAP1 | |
| SCHEMBL14415380 | 0.88 | REN (0.60) | RENCTSDMETAP2CPB2METAP1 | |
| SCHEMBL9685661 | 0.86 | REN (0.56) | RENMETAP2METAP1 | |
| SCHEMBL9575386 | 0.86 | REN (0.56) | RENMETAP2METAP1 | |
| SCHEMBL9858518 | 0.86 | REN (0.56) | RENMETAP2METAP1 | |
| SCHEMBL7296545 | 0.84 | REN (0.79) | RENMETAP2 | |
| SCHEMBL14415355 | 0.84 | REN (0.79) | RENMETAP2 | |
| SCHEMBL7284318 | 0.84 | REN (0.79) | RENMETAP2 | |
| SCHEMBL9575598 | 0.84 | REN (0.79) | RENMETAP2 | |
| SCHEMBL9858453 | 0.84 | REN (0.79) | RENMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703129-A | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-12-30 | — | — | US | disclosed |