SCHEMBL8828166

SCHEMBL8828166

CCC(Cc1ccc(-n2ccnc2)s1)C(=O)O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.36
BAZ2B Q9UIF8 1/20 0.36
NR4A2 P43354 1/20 0.35
ADH5 P11766 3/20 0.35
TBXAS1 P24557 5/20 0.34
HTT P42858 1/20 0.34
ALDH1A1 P00352 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
CYP19A1 P11511 2/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
MITF O75030 1/20 0.34
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.34
MAOB P27338 1/20 0.32
PDE4A P27815 1/20 0.32
PDE4B Q07343 1/20 0.32
PDE4C Q08493 1/20 0.32
PDE4D Q08499 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10726954 0.81 STING1 (0.42) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL8828396 0.77 CYP3A4 (0.38) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL10365542 0.76 CYP3A4 (0.39) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL10364629 0.76 CYP3A4 (0.44) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL10724660 0.76 MMP2 (0.36) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL10363622 0.74 CYP3A4 (0.38) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL10729834 0.74 STING1 (0.44) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL10364635 0.72 CYP3A4 (0.39) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL10729354 0.70 STING1 (0.40) CYP3A4BAZ2BTBXAS1
SCHEMBL10724974 0.69 TBXAS1 (0.34) CYP3A4BAZ2BADH5TBXAS1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5607953-A ANTIISCHEMIC AGENTS EISAI CO., LTD. (JP) 1997-03-04 US disclosed
EP-0344577-B1 Butenoic or propenoic acid derivatives EISAI CO LTD (JP) 1996-10-09 EP disclosed
US-5382595-A Antiischemic agents EISAI CO., LTD. (JP) 1995-01-17 US disclosed
US-5177089-A Antiischemic agent, vasodilator EISAI CO., LTD. (JP) 1993-01-05 US disclosed
EP-0344577-A2 Butenoic or propenoic acid derivatives Eisai Co., Ltd. (JP) 1989-12-06 EP disclosed