SCHEMBL8828396

SCHEMBL8828396

CCC(Cc1cc(-n2ccnc2)cs1)C(=O)O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.38
BAZ2B Q9UIF8 1/20 0.38
ADH5 P11766 7/20 0.36
TBXAS1 P24557 2/20 0.36
HTT P42858 1/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
MITF O75030 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
PDE4A P27815 2/20 0.34
PDE4B Q07343 2/20 0.34
PDE4C Q08493 2/20 0.34
PDE4D Q08499 2/20 0.34
MAOB P27338 1/20 0.34
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP19A1 P11511 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10364581 0.77 CYP3A4 (0.41) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL10365545 0.77 CYP3A4 (0.47) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL8828166 0.77 CYP3A4 (0.36) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL10365503 0.75 CYP3A4 (0.40) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL10363602 0.73 CYP3A4 (0.41) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL10645502 0.71 STING1 (0.39) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL10648270 0.69 TBXAS1 (0.40) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL10651014 0.67 TBXAS1 (0.48) CYP3A4BAZ2BADH5TBXAS1HTT
SCHEMBL14307267 0.66 CYP3A4 (0.46) CYP3A4BAZ2BHTTMEN1MAPT
SCHEMBL8828392 0.66 TBXAS1 (0.41) CYP3A4BAZ2BADH5TBXAS1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5607953-A ANTIISCHEMIC AGENTS EISAI CO., LTD. (JP) 1997-03-04 US disclosed
EP-0344577-B1 Butenoic or propenoic acid derivatives EISAI CO LTD (JP) 1996-10-09 EP disclosed
US-5382595-A Antiischemic agents EISAI CO., LTD. (JP) 1995-01-17 US disclosed
EP-0344577-A2 Butenoic or propenoic acid derivatives Eisai Co., Ltd. (JP) 1989-12-06 EP disclosed