Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046857 | 0.87 | OPRM1 (0.44) | SMN1; SMN2OPRM1TMEM97SIGMAR1MAPT | |
| SCHEMBL8828221 | 0.85 | OPRM1 (0.48) | SMN1; SMN2OPRM1TMEM97SIGMAR1MAPT | |
| SCHEMBL8828242 | 0.84 | OPRM1 (0.49) | SMN1; SMN2OPRM1TMEM97SIGMAR1MAPT | |
| SCHEMBL8828131 | 0.84 | CYP3A4 (0.52) | OPRM1TMEM97SIGMAR1MAPTCYP3A4 | |
| SCHEMBL8828140 | 0.84 | OPRM1 (0.44) | SMN1; SMN2OPRM1TMEM97SIGMAR1MAPT | |
| SCHEMBL9044237 | 0.84 | OPRM1 (0.44) | SMN1; SMN2OPRM1TMEM97SIGMAR1MAPT | |
| SCHEMBL8828147 | 0.83 | MAPT (0.56) | OPRM1TMEM97SIGMAR1MAPTCYP3A4 | |
| SCHEMBL8828235 | 0.83 | MAPT (0.56) | SMN1; SMN2OPRM1TMEM97SIGMAR1MAPT | |
| SCHEMBL8828122 | 0.83 | OPRM1 (0.46) | SMN1; SMN2OPRM1TMEM97SIGMAR1MAPT | |
| SCHEMBL8828274 | 0.83 | OPRM1 (0.49) | OPRM1TMEM97SIGMAR1MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607953-A | ANTIISCHEMIC AGENTS | EISAI CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | disclosed |
| US-5382595-A | Antiischemic agents | EISAI CO., LTD. (JP) | 1995-01-17 | — | — | US | disclosed |
| US-5177089-A | Antiischemic agent, vasodilator | EISAI CO., LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | disclosed |