Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828233 | 0.91 | OPRM1 (0.47) | OPRM1TMEM97SIGMAR1SMN1; SMN2CYP3A4 | |
| SCHEMBL8828131 | 0.89 | CYP3A4 (0.52) | OPRM1TMEM97SIGMAR1KDM4ECYP3A4 | |
| SCHEMBL9044237 | 0.89 | OPRM1 (0.44) | OPRM1TMEM97SIGMAR1KDM4ESMN1; SMN2 | |
| SCHEMBL9160110 | 0.89 | PTAFR (0.47) | OPRM1TMEM97SIGMAR1SMN1; SMN2CYP3A4 | |
| SCHEMBL8828147 | 0.88 | MAPT (0.56) | OPRM1TMEM97SIGMAR1CYP3A4CYP1A2 | |
| SCHEMBL8828235 | 0.88 | MAPT (0.56) | OPRM1TMEM97SIGMAR1KDM4ESMN1; SMN2 | |
| SCHEMBL8828242 | 0.88 | OPRM1 (0.49) | OPRM1TMEM97SIGMAR1KDM4ESMN1; SMN2 | |
| SCHEMBL8828188 | 0.88 | LMNA (0.49) | OPRM1TMEM97SIGMAR1SMN1; SMN2CYP3A4 | |
| SCHEMBL8828274 | 0.88 | OPRM1 (0.49) | OPRM1TMEM97SIGMAR1KDM4ECYP3A4 | |
| SCHEMBL8828252 | 0.88 | MAPT (0.49) | OPRM1TMEM97SIGMAR1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | claimed |
| US-5607953-A | ANTIISCHEMIC AGENTS | EISAI CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | disclosed |
| US-5382595-A | Antiischemic agents | EISAI CO., LTD. (JP) | 1995-01-17 | — | — | US | disclosed |
| US-5177089-A | Antiischemic agent, vasodilator | EISAI CO., LTD. (JP) | 1993-01-05 | — | — | US | disclosed |