Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CRHBP | P24387 | 2/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | EBP | Q15125 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739796 | 0.88 | MAPK1 (0.57) | MAPK1SMN1; SMN2ALDH1A1CRHBPCRHR2 | |
| SCHEMBL8828243 | 0.87 | MAPK1 (0.58) | MAPK1SMN1; SMN2ALDH1A1CRHBPCRHR2 | |
| SCHEMBL8828205 | 0.84 | MAPK1 (0.60) | MAPK1SMN1; SMN2ALDH1A1CRHBPCRHR2 | |
| SCHEMBL8828284 | 0.83 | MAPK1 (0.53) | MAPK1SMN1; SMN2ALDH1A1KDM4ESIGMAR1 | |
| SCHEMBL8828287 | 0.83 | MAPK1 (0.53) | MAPK1SMN1; SMN2ALDH1A1KDM4ESIGMAR1 | |
| SCHEMBL26024359 | 0.82 | MAPK1 (0.55) | MAPK1SMN1; SMN2ALDH1A1KDM4ESIGMAR1 | |
| SCHEMBL8828312 | 0.81 | MAPK1 (0.57) | MAPK1SMN1; SMN2ALDH1A1CRHBPCRHR2 | |
| SCHEMBL8828191 | 0.81 | SPHK2 (0.58) | MAPK1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8828199 | 0.81 | SPHK2 (0.58) | MAPK1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL5191198 | 0.81 | MAPK1 (0.56) | MAPK1SMN1; SMN2ALDH1A1CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0224794-B1 | CYCLIC AMINE DERIVATIVES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1990-09-12 | — | — | EP | disclosed |
| EP-0224794-A2 | Cyclic amine derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-06-10 | — | — | EP | disclosed |