Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAM | P19021 | 1/20 | 0.56 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.54 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.54 |
| ▸ | PYGL | P06737 | 11/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GUSB | P08236 | 1/20 | 0.44 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828326 | 1.00 | PAM (0.56) | PAMGRIK1GRIK2PYGLALDH1A1 | |
| SCHEMBL28564125 | 0.85 | PAM (0.51) | PAMGRIK1GRIK2PYGLALDH1A1 | |
| SCHEMBL8063786 | 0.83 | GRIK1 (0.51) | GRIK1GRIK2PYGLALDH1A1GUSB | |
| SCHEMBL9492222 | 0.80 | PYGL (0.46) | GRIK1GRIK2PYGLALDH1A1GUSB | |
| SCHEMBL9046738 | 0.79 | PAM (0.68) | PAMGRIK1GRIK2ALDH1A1 | |
| SCHEMBL9046744 | 0.79 | PAM (0.68) | PAMGRIK1GRIK2ALDH1A1 | |
| Acetic Acid SCHEMBL6974964 | 0.79 | GRIK1 (0.51) | GRIK1GRIK2PYGLALDH1A1GUSB | |
| SCHEMBL3743993 | 0.77 | ALDH1A1 (0.57) | GRIK1GRIK2PYGLALDH1A1GUSB | |
| SCHEMBL2092421 | 0.77 | ALDH1A1 (0.54) | GRIK1GRIK2PYGLALDH1A1GUSB | |
| SCHEMBL2092419 | 0.77 | ALDH1A1 (0.54) | GRIK1GRIK2PYGLALDH1A1GUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607953-A | ANTIISCHEMIC AGENTS | EISAI CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | disclosed |
| US-5382595-A | Antiischemic agents | EISAI CO., LTD. (JP) | 1995-01-17 | — | — | US | disclosed |
| US-5177089-A | Antiischemic agent, vasodilator | EISAI CO., LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | disclosed |