Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAM | P19021 | 1/20 | 0.58 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828328 | 1.00 | PAM (0.58) | PAMNFE2L2MAOBCYP1A2CYP1B1 | |
| SCHEMBL24536155 | 0.86 | PAM (0.50) | PAMNFE2L2CYP2D6 | |
| SCHEMBL27301670 | 0.83 | PAM (0.47) | PAMNFE2L2MAOBCYP2D6RAB9A | |
| SCHEMBL30942501 | 0.83 | PAM (0.47) | PAMNFE2L2MAOBCYP2D6RAB9A | |
| SCHEMBL27799088 | 0.79 | PAM (0.60) | PAMMAOBCYP2D6SMN1; SMN2 | |
| SCHEMBL9150858 | 0.79 | PAM (0.60) | PAMNFE2L2CYP1B1CYP1A1MAPT | |
| SCHEMBL30443677 | 0.78 | PAM (0.58) | PAMMAOBCYP1A2CYP1B1CYP2D6 | |
| SCHEMBL15540625 | 0.78 | PAM (0.58) | PAMMAOBCYP1A2CYP1B1CYP2D6 | |
| SCHEMBL15540628 | 0.78 | PAM (0.58) | PAMMAOBCYP1A2CYP1B1CYP2D6 | |
| SCHEMBL28010950 | 0.78 | PAM (0.58) | PAMMAOBCYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607953-A | ANTIISCHEMIC AGENTS | EISAI CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | disclosed |
| US-5382595-A | Antiischemic agents | EISAI CO., LTD. (JP) | 1995-01-17 | — | — | US | disclosed |
| US-5177089-A | Antiischemic agent, vasodilator | EISAI CO., LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | disclosed |