Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 3/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 2/20 | 0.33 |
| ▸ | FNTB | P49356 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28197295 | 0.81 | GAA (0.36) | MAPTALDH1A1PKMCA1CA2 | |
| SCHEMBL27738869 | 0.81 | POLB (0.36) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL31506472 | 0.80 | KDM4E (0.39) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL29631981 | 0.79 | KDM4E (0.42) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL31589432 | 0.79 | ALDH1A1 (0.50) | MAPTACEFOLH1ALDH1A1 | |
| SCHEMBL31171291 | 0.79 | FPR2 (0.40) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL31590099 | 0.77 | CA12 (0.36) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL30332077 | 0.75 | FOLH1 (0.45) | ACEFOLH1CA1CA2 | |
| SCHEMBL30480270 | 0.73 | — | — | |
| SCHEMBL11360473 | 0.73 | ALDH1A1 (0.47) | KDM4EMAPTNFKB1PTGS2FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5635593-A | TWO OR MORE BRADYKININ ANTAGONIST PEPTIDES CHEMICALLY LINKED BY ONE OR MORE SUCCINIMIDO GROUP VIA THIOETHER BOND TO FORM DIMER OR HIGHER OLIGOMER | CORTECH, INC. (US) | 1997-06-03 | — | — | US | disclosed |
| US-5620958-A | DIMERIZED PEPTIDES HAVING A BISSUCCINIMIDO GROUP ATTACHED TO CYSTEINE THIO GROUP; ANALGESICS FOR SEVERE PAIN | CORETECH, INC. (US) | 1997-04-15 | — | — | US | disclosed |
| WO-1992017201-A1 | BRADYKININ ANTAGONISTS | CORTECH, INC. (US) | 1992-10-15 | — | — | WO | disclosed |