SCHEMBL882952

SCHEMBL882952

NC(=O)c1cccc(NC(=O)OCC2c3ccccc3-c3ccccc32)c1

nearest known ligand 0.72

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ EPHX2 P34913 1/20 0.72
▸ KMT2A Q03164 3/20 0.52
▸ MEN1 O00255 1/20 0.48
▸ HPGD P15428 2/20 0.45
▸ PARP1 P09874 9/20 0.43
▸ PARP10 Q53GL7 9/20 0.43
▸ PARP15 Q460N3 4/20 0.43
▸ PARP14 Q460N5 4/20 0.43
▸ LMNA P02545 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ TPSAB1 Q15661 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29400630 0.89 EPHX2 (0.73) EPHX2KMT2AMEN1HPGDLMNA
SCHEMBL30089345 0.89 EPHX2 (0.73) EPHX2KMT2AMEN1HPGDLMNA
SCHEMBL118921 0.89 EPHX2 (0.73) EPHX2KMT2AMEN1HPGDLMNA
SCHEMBL12235823 0.87 EPHX2 (0.70) EPHX2KMT2AMEN1HPGDRAB9A
SCHEMBL30877549 0.83 EPHX2 (0.72) EPHX2KMT2A
SCHEMBL8366872 0.83 EPHX2 (0.75) EPHX2KMT2AMEN1RAB9A
SCHEMBL16977027 0.82 EPHX2 (0.75) EPHX2KMT2ALMNA
SCHEMBL694173 0.82 EPHX2 (0.75) EPHX2KMT2AHPGDLMNA
SCHEMBL4099152 0.82 EPHX2 (0.75) EPHX2KMT2ALMNA
SCHEMBL1252684 0.82 EPHX2 (0.67) EPHX2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230346946-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2023-11-02 — — US disclosed
US-20230346946-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2023-11-02 — — US disclosed
US-11672864-B2 Nanostructured gels capable of controlled release of encapsulated agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2023-06-13 — — US disclosed
EP-3412279-B1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCAPSULATED AGENTS BRIGHAM & WOMENS HOSPITAL INC (US) 2021-02-17 — — EP disclosed
US-20210008213-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCAPSULATED AGENTS THE GENERAL HOSPITAL CORPORATION 2021-01-14 — — US disclosed
US-10675351-B2 Nanostructured gels capable of controlled release of encapsulated agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2020-06-09 — — US disclosed
US-9974859-B2 Nanostructured gels capable of controlled release of entrapped agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2018-05-22 — — US disclosed
US-20170000888-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENTRAPPED AGENTS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2017-01-05 — — US disclosed
US-20130280334-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2013-10-24 — — US disclosed
WO-2012040623-A2 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCAPSULATED AGENTS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2012-03-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210008213-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCAPSULATED AGENTS MMP2, CEL, LIPA EPHX2 231/4885KMT2A 3895/4885MEN1 3515/4885
US-20230346946-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents MMP2, CEL, LIPA EPHX2 231/4885KMT2A 3895/4885MEN1 3515/4885
US-20130280334-A1 Nanostructured Gels Capable of Controlled Release of Encapsulated Agents MMP2, CEL, LIPA EPHX2 231/4885KMT2A 3895/4885MEN1 3515/4885
US-20170000888-A1 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENTRAPPED AGENTS MMP2, MMP1, GUSB EPHX2 112/4885KMT2A 4034/4885MEN1 3859/4885
US-10675351-B2 Nanostructured gels capable of controlled release of encapsulated agents MMP2, CEL, LIPA EPHX2 231/4885KMT2A 3895/4885MEN1 3515/4885
US-11672864-B2 Nanostructured gels capable of controlled release of encapsulated agents MMP2, CEL, LIPA EPHX2 231/4885KMT2A 3895/4885MEN1 3515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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