Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.49 |
| ▸ | CDC7 | O00311 | 6/20 | 0.48 |
| ▸ | DBF4 | Q9UBU7 | 6/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874365 | 0.88 | GAA (0.47) | TRPM8CDC7DBF4MAPTKDM4E | |
| SCHEMBL3864037 | 0.75 | CDC7 (0.64) | TRPM8CDC7DBF4KDM4EGAA | |
| SCHEMBL882720 | 0.74 | KDM4E (0.53) | L3MBTL1MAPTKDM4EGAAMEN1 | |
| SCHEMBL2823339 | 0.73 | CDC7 (0.73) | TRPM8CDC7DBF4MAPTKDM4E | |
| SCHEMBL10069158 | 0.73 | CD274 (0.41) | MAPTALDH1A1LMNAPPARANPC1 | |
| SCHEMBL5192927 | 0.72 | KDM4E (0.57) | TRPM8CDC7DBF4MAPTKDM4E | |
| SCHEMBL17374792 | 0.72 | CDC7 (0.56) | TRPM8CDC7DBF4L3MBTL1MAPT | |
| SCHEMBL3823856 | 0.72 | TRPM8 (0.56) | TRPM8MAPTKDM4EGAAMEN1 | |
| SCHEMBL15049127 | 0.72 | TRPM8 (0.62) | TRPM8CDC7DBF4MAPTKDM4E | |
| SCHEMBL5255659 | 0.71 | SMN1; SMN2 (0.57) | TRPM8CDC7DBF4L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |