Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875967 | 0.83 | NAMPT (0.40) | PPARAACVR1 | |
| SCHEMBL875667 | 0.80 | CD274 (0.42) | CD274SCN9ATSHRALDH1A1CYP1A2 | |
| SCHEMBL883091 | 0.75 | NAMPT (0.36) | CD274ALDH1A1MAPTPPARAHDAC2 | |
| SCHEMBL874365 | 0.74 | GAA (0.47) | NPC1HPGDALDH1A1MAPTPPARA | |
| SCHEMBL874755 | 0.73 | NAMPT (0.47) | — | |
| SCHEMBL883107 | 0.73 | TRPM8 (0.49) | NPC1HPGDALDH1A1MAPTPPARA | |
| SCHEMBL875067 | 0.73 | NAMPT (0.44) | — | |
| SCHEMBL874409 | 0.72 | CD274 (0.55) | CD274TSHRHPGDALDH1A1CYP1A2 | |
| SCHEMBL877527 | 0.69 | IKBKB (0.44) | CD274SCN9ACYP1A2CYP2C9 | |
| SCHEMBL3433998 | 0.69 | TGFBR1 (0.37) | TSHRHPGDALDH1A1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |