Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | ACP3 | P15309 | 2/20 | 0.33 |
| ▸ | NMT2 | O60551 | 2/20 | 0.33 |
| ▸ | NMT1 | P30419 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9178631 | 0.80 | ACP3 (0.46) | HPGDKDM4ELMNAALDH1A1L3MBTL1 | |
| SCHEMBL8938035 | 0.67 | ACP3 (0.67) | HPGDKDM4ELMNANR1I2ALDH1A1 | |
| SCHEMBL16204385 | 0.64 | MEN1 (0.41) | NPSR1 | |
| SCHEMBL10391193 | 0.63 | KMT2A (0.56) | HPGDKDM4ELMNAALDH1A1NMT2 | |
| SCHEMBL10389688 | 0.63 | MEN1 (0.46) | HPGDKDM4EALDH1A1NMT2NMT1 | |
| SCHEMBL518217 | 0.63 | POLB (0.44) | HPGDKDM4ELMNANR1I2ALDH1A1 | |
| SCHEMBL28675931 | 0.63 | CA1 (0.37) | HPGDKDM4ELMNAALDH1A1ACP3 | |
| SCHEMBL10786887 | 0.63 | KDM4E (0.57) | HPGDKDM4ELMNANR1I2ALDH1A1 | |
| SCHEMBL31482558 | 0.63 | KDM4E (0.57) | HPGDKDM4ELMNANR1I2ALDH1A1 | |
| SCHEMBL10631805 | 0.61 | KDM4E (0.54) | HPGDKDM4ELMNANR1I2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5412141-A | Bisphosphonic acid derivatives as anti-arthritic agents | THE UPJOHN COMPANY (US) | 1995-05-02 | — | — | US | claimed |
| EP-0544812-B1 | BISPHOSPHONIC ACID DERIVATIVES AS ANTI-ARTHRITIC AGENTS | UPJOHN CO (US) | 1995-04-05 | — | — | EP | claimed |
| EP-0544812-A1 | BISPHOSPHONIC ACID DERIVATIVES AS ANTI-ARTHRITIC AGENTS. | UPJOHN CO (US) | 1993-06-09 | — | — | EP | claimed |
| WO-1992003451-A1 | BISPHOSPHONIC ACID DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1992-03-05 | — | — | WO | claimed |
| US-5602115-A | Bisphosphonic acid derivatives as anti-arthritic agents | THE UPJOHN COMPANY (US) | 1997-02-11 | — | — | US | disclosed |