Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622367 | 0.83 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AMAPK1NPSR1 | |
| SCHEMBL27846776 | 0.81 | MAPK1 (0.57) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL28665104 | 0.80 | ALOX15 (0.46) | ALDH1A1MEN1KMT2AMAPK1RAB9A | |
| SCHEMBL11523079 | 0.78 | MEN1 (0.57) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL14712316 | 0.78 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL13034149 | 0.77 | MEN1 (0.58) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL14707337 | 0.77 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL9340087 | 0.76 | ALDH1A1 (0.65) | ALDH1A1KMT2AMAPK1TDP1TSHR | |
| SCHEMBL3003431 | 0.76 | ALDH1A1 (0.65) | ALDH1A1KMT2AMAPK1TDP1TSHR | |
| SCHEMBL8333813 | 0.76 | ALDH1A1 (0.65) | ALDH1A1KMT2AMAPK1TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616803-A | EXHIBIT SQUALENE SYNTHASE-INHIBITORY ACTIVITIES; USEFUL IN TREATMENT AND PROPHYLAXIS OF HYPERCHOLESTEREMIA, HYPERLIPEMIA AND ARTERIOSCLEROSIS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1997-04-01 | — | — | US | disclosed |