Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.40 |
| ▸ | ERN1 | O75460 | 3/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21105283 | 0.89 | MEN1 (0.38) | ACHEERN1HRH4HRH3TGM2 | |
| SCHEMBL3676772 | 0.86 | TGM2 (0.46) | ACHEERN1TGM2EPHX2TSHR | |
| SCHEMBL24660419 | 0.85 | HRH4 (0.49) | ACHEERN1HRH4HRH3TGM2 | |
| SCHEMBL13055388 | 0.84 | MAPT (0.42) | ACHEERN1HRH4HRH3MEN1 | |
| SCHEMBL15809690 | 0.83 | ACHE (0.46) | ACHEERN1HRH4HRH3TGM2 | |
| SCHEMBL4678545 | 0.83 | ACHE (0.41) | ACHEERN1HRH4HRH3TGM2 | |
| SCHEMBL8781903 | 0.82 | MEN1 (0.39) | ACHEERN1HRH4HRH3MEN1 | |
| SCHEMBL15109209 | 0.81 | ALDH1A1 (0.46) | ACHEERN1HRH4HRH3TGM2 | |
| SCHEMBL8769203 | 0.81 | ACHE (0.63) | ACHETSHR | |
| SCHEMBL9547242 | 0.81 | ERN1 (0.40) | ACHEERN1HRH4HRH3TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5608056-A | Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0636133-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021186-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-28 | — | — | WO | disclosed |