Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | GFER | P55789 | 1/20 | 0.67 |
| ▸ | NGLY1 | Q96IV0 | 1/20 | 0.67 |
| ▸ | FABP4 | P15090 | 1/20 | 0.66 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.59 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.59 |
| ▸ | CTSV | O60911 | 1/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL351705 | 0.91 | MAPT (0.79) | MAPTGFERNGLY1FABP4AKR1C3 | |
| SCHEMBL9409097 | 0.91 | MAPT (0.57) | MAPTGFERNGLY1FABP4AKR1C3 | |
| SCHEMBL9172301 | 0.89 | MAPT (0.76) | MAPTGFERNGLY1FABP4AKR1C3 | |
| SCHEMBL9409037 | 0.84 | MAPT (0.54) | MAPTGFERNGLY1FABP4AKR1C3 | |
| SCHEMBL2723037 | 0.83 | SIRT2 (0.58) | MAPTGFERNGLY1FABP4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28298843 | 0.83 | MAPT (0.73) | MAPTGFERNGLY1FABP4AKR1C3 | |
| SCHEMBL8002116 | 0.83 | MAPT (0.67) | MAPTGFERNGLY1FABP4AKR1C3 | |
| Fenamic Acid SCHEMBL29622832 | 0.83 | FABP4 (0.92) | MAPTGFERNGLY1FABP4AKR1C3 | |
| Fenamic Acid SCHEMBL25828 | 0.83 | FABP4 (0.92) | MAPTGFERNGLY1FABP4AKR1C3 | |
| SCHEMBL19334478 | 0.82 | MAPT (0.53) | MAPTGFERNGLY1FABP4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663336-A | IMIDATION OF DIAMINOPHTHALIC ACID TO FORM KINASE INHIBITORS AS ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5491144-A | KINASE INHIBITORS, ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-02-13 | — | — | US | disclosed |
| EP-0600831-A1 | Phtalazinon derivatives | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | disclosed |
| EP-0600832-A1 | Derivatives of diamino benzoic and diamino phthalic acid und their use as protein linase inhibitors | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | disclosed |