Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | NGLY1 | Q96IV0 | 1/20 | 0.57 |
| ▸ | FABP4 | P15090 | 1/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | CTSV | O60911 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2723037 | 0.94 | SIRT2 (0.58) | MAPTGFERNGLY1FABP4SIRT2 | |
| SCHEMBL8833788 | 0.91 | MAPT (0.67) | MAPTGFERNGLY1FABP4AKR1C3 | |
| SCHEMBL8002116 | 0.89 | MAPT (0.67) | MAPTGFERNGLY1FABP4SIRT2 | |
| SCHEMBL9409202 | 0.83 | MAPT (0.64) | MAPTSIRT2SIRT1AKR1C3AKR1C2 | |
| SCHEMBL351705 | 0.83 | MAPT (0.79) | MAPTGFERNGLY1FABP4AKR1C3 | |
| SCHEMBL9409089 | 0.82 | FABP4 (0.61) | MAPTFABP4SIRT2SIRT1AKR1C3 | |
| SCHEMBL9409154 | 0.82 | AKR1C3 (0.55) | MAPTGFERSIRT2AKR1C3AKR1C2 | |
| SCHEMBL9409032 | 0.81 | SIRT2 (0.59) | SIRT2SIRT1AKR1C3AKR1C2 | |
| SCHEMBL19934325 | 0.81 | MAPT (0.56) | MAPTGFERNGLY1FABP4SIRT2 | |
| SCHEMBL9172301 | 0.81 | MAPT (0.76) | MAPTGFERNGLY1FABP4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600832-A1 | Derivatives of diamino benzoic and diamino phthalic acid und their use as protein linase inhibitors | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | claimed |
| EP-0600832-A1 | Derivatives of diamino benzoic and diamino phthalic acid und their use as protein linase inhibitors | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | disclosed |