Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6643061 | 0.88 | NPC1 (0.59) | GRM4NPC1HPGDHTTKMT2A | |
| SCHEMBL16638715 | 0.87 | MEN1 (0.44) | GRM4NPC1HPGDHTTKMT2A | |
| SCHEMBL9402383 | 0.86 | RAB9A (0.57) | NPC1HPGDHTTKMT2ARAB9A | |
| SCHEMBL1376342 | 0.80 | DHODH (0.56) | GRM4NPC1HTTKMT2ARAB9A | |
| SCHEMBL6644285 | 0.76 | MAP4K4 (0.43) | NPC1HTTKMT2ARAB9ADHODH | |
| SCHEMBL16627428 | 0.76 | MEN1 (0.49) | NPC1HTTKMT2ARAB9AMEN1 | |
| SCHEMBL9402324 | 0.76 | DHODH (0.57) | GRM4NPC1KMT2ARAB9AMEN1 | |
| SCHEMBL10835241 | 0.76 | RAB9A (0.56) | NPC1HPGDHTTKMT2ARAB9A | |
| SCHEMBL10674155 | 0.76 | LMNA (0.59) | GRM4NPC1HTTKMT2ARAB9A | |
| SCHEMBL9402355 | 0.76 | GRM4 (0.52) | GRM4NPC1HPGDHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663181-A | Naphthyridine derivatives, their methods of preparation and pharmaceutical compositions in which they are present, useful especially as antiproliferative drugs | LABORATOIRES UPSA (FR) | 1997-09-02 | — | — | US | disclosed |
| US-5364860-A | Naphthyridine compounds which inhibit tyrosine kinase and their pharmaceutical compositions | LABORATOIRES UPSA (FR) | 1994-11-15 | — | — | US | disclosed |