Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.52 |
| ▸ | CDC25C | P30307 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8836082 | 1.00 | ACHE (0.52) | ACHECDC25CCYP19A1PTGS2SMN1; SMN2 | |
| SCHEMBL8790218 | 0.88 | PTGS2 (0.60) | ACHECDC25CCYP19A1PTGS2SMN1; SMN2 | |
| SCHEMBL8790222 | 0.88 | PTGS2 (0.60) | ACHECDC25CCYP19A1PTGS2SMN1; SMN2 | |
| SCHEMBL3143902 | 0.86 | ACHE (0.65) | ACHECDC25CCYP19A1PTGS2SMN1; SMN2 | |
| SCHEMBL8790080 | 0.81 | CYP19A1 (0.54) | ACHECYP19A1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL8790071 | 0.81 | CYP19A1 (0.54) | ACHECYP19A1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL3153190 | 0.79 | CDC25C (0.67) | ACHECDC25CSMN1; SMN2KCNH2KMT2A | |
| SCHEMBL9827783 | 0.78 | PTGS2 (0.68) | CYP19A1PTGS2SMN1; SMN2LMNAKMT2A | |
| SCHEMBL9827777 | 0.78 | PTGS2 (0.68) | CYP19A1PTGS2SMN1; SMN2LMNAKMT2A | |
| SCHEMBL8789055 | 0.77 | ACHE (0.58) | ACHECDC25CSMN1; SMN2LMNAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0569380-A1 | ACRIDINE DERIVATIVES. | GLAXO LAB SA (FR) | 1993-11-18 | — | — | EP | disclosed |
| WO-1992012132-A1 | ACRIDINE DERIVATIVES | LABORATOIRES GLAXO S.A. (FR) | 1992-07-23 | — | — | WO | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |