Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8836218 | 0.99 | KDM4E (0.38) | KDM4EHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL8835677 | 0.82 | TSHR (0.43) | KDM4EHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL8836665 | 0.79 | L3MBTL1 (0.41) | KDM4EALDH1A1TSHRLMNAPOLB | |
| SCHEMBL8836310 | 0.78 | ALDH1A1 (0.40) | KDM4EHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL8835790 | 0.77 | ALDH1A1 (0.42) | KDM4EHDAC1HDAC6HDAC3HDAC2 | |
| Hydrochloric Acid SCHEMBL8836216 | 0.77 | ALDH1A1 (0.39) | KDM4EHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL9433323 | 0.75 | MAPT (0.45) | KDM4EALDH1A1TSHRLMNAPOLB | |
| SCHEMBL8835670 | 0.75 | ALDH1A1 (0.48) | ALDH1A1TSHRPOLBMAPTNPSR1 | |
| Hydrochloric Acid SCHEMBL8835787 | 0.74 | MAPT (0.44) | KDM4EALDH1A1TSHRLMNAPOLB | |
| SCHEMBL8836567 | 0.72 | PTGES (0.40) | KDM4ETSHRLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5319096-A | Neuroprotective agent | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-06-07 | — | — | US | claimed |
| US-5646300-A | NEUROPROTECTIVE AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5591866-A | NEUROPROTECTIVE AGENTS | HOECHST MARION ROUSSEL INC. (US) | 1997-01-07 | — | — | US | disclosed |
| US-5565579-A | NEUROPROTECTIVE AGENT | HOECHST MARION ROUSSEL INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0563916-B1 | (1H-Indol-1-yl)-2-(amino)acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, intermediates and a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-08-16 | — | — | EP | disclosed |
| US-5319096-A | Neuroprotective agent | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0563916-A1 | (1H-Indol-1-yl)-2-(amino)acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, intermediates and a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-10-06 | — | — | EP | disclosed |