Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.51 |
| ▸ | GCGR | P47871 | 2/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.41 |
| ▸ | WNT1 | P04628 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177789 | 0.79 | MAPK14 (0.59) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| SCHEMBL7491106 | 0.79 | MAPK14 (0.59) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| SCHEMBL8836352 | 0.77 | KDM4E (0.50) | MAPK14MAPK11 | |
| SCHEMBL23557736 | 0.75 | MAPK14 (0.52) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| SCHEMBL25219016 | 0.74 | CCNC (0.42) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| SCHEMBL8836207 | 0.74 | MAPK14 (0.59) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| SCHEMBL5454909 | 0.74 | MAPK14 (0.51) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| SCHEMBL20075104 | 0.72 | ALDH1A1 (0.45) | MAPK14KDR | |
| SCHEMBL1554749 | 0.70 | MAPK14 (0.56) | MAPK14MAPK11MAPK13GCGRMAPK12 | |
| SCHEMBL8836677 | 0.70 | TGFBR1 (0.49) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624931-A | Pyrazole derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-29 | — | — | US | disclosed |
| US-5478827-A | Inhibits Interleukin-1 and tumor necrosis factor production | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5356897-A | Inhibit the production of Interleukin-1 and tumor necrosis factor; administering for treatment of chronic inflammatory diseases, autoimmune diseases and sepsis-induced organ injury | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-18 | — | — | US | disclosed |
| CN-1075965-A | New Hete rocyclic derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1993-09-08 | — | — | CN | disclosed |
| CN-1070404-A | New Hete rocyclic derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1993-03-31 | — | — | CN | disclosed |
| EP-0531901-A2 | Condensed pyrazole derivatives with interleukin-1 and tumour necrosis factor inhibitory activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |