Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | PPARD | Q03181 | 4/20 | 0.50 |
| ▸ | PPARA | Q07869 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876364 | 0.85 | LTA4H (0.47) | PPARGPPARAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL876543 | 0.83 | TLR8 (0.48) | PPARGKDM4EALDH1A1SMN1; SMN2LTA4H | |
| SCHEMBL16199417 | 0.83 | LTA4H (0.45) | PPARGPPARDPPARAKDM4EALDH1A1 | |
| SCHEMBL21701049 | 0.82 | ALDH1A1 (0.49) | KDM4EALDH1A1LTA4HF10MAPT | |
| SCHEMBL875891 | 0.81 | CYP1A2 (0.48) | KDM4ESMN1; SMN2LTA4HMAPK14MAOB | |
| SCHEMBL6499332 | 0.80 | MAPT (0.44) | PPARGPPARDPPARAKDM4EALDH1A1 | |
| SCHEMBL19427261 | 0.80 | LTA4H (0.53) | LTA4HNR1H2MEN1KMT2A | |
| SCHEMBL5112247 | 0.79 | DAO (0.46) | S1PR1KIF11 | |
| SCHEMBL875576 | 0.79 | LTA4H (0.58) | PPARGPPARAALDH1A1SMN1; SMN2LTA4H | |
| SCHEMBL24155484 | 0.78 | MAPT (0.50) | KDM4EALDH1A1LTA4HF10MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037782-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES | GLAXO GROUP LIMITED (GB) | 2012-03-29 | — | — | WO | disclosed |