Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5545141 | 0.84 | POLB (0.44) | POLBALDH1A1TP53KDM4EGLA | |
| SCHEMBL9503721 | 0.78 | ALDH1A1 (0.49) | POLBALDH1A1TP53KDM4EGLA | |
| SCHEMBL6364898 | 0.78 | TDP1 (0.52) | POLBALDH1A1TP53KDM4EGLA | |
| SCHEMBL11685677 | 0.77 | TNF (0.52) | POLBALDH1A1TP53KDM4EGLA | |
| SCHEMBL14114811 | 0.76 | TDP1 (0.53) | POLBALDH1A1TP53KDM4EGLA | |
| SCHEMBL7342436 | 0.76 | MMP2 (0.52) | ALDH1A1 | |
| SCHEMBL15537671 | 0.76 | TNF (0.46) | POLBALDH1A1TP53KDM4EGLA | |
| SCHEMBL14479254 | 0.75 | TDP1 (0.44) | POLBALDH1A1TP53KDM4EGLA | |
| SCHEMBL15241103 | 0.75 | TDP1 (0.46) | POLBALDH1A1TP53KDM4EGLA | |
| SCHEMBL7054656 | 0.75 | TDP1 (0.46) | POLBALDH1A1TP53KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330625-B1 | Total synthesis method for making an indole structure derivative product class, of the triptamine type, in particular, melatonin or N-acetyl-5-methoxytriptamine type, having a high purity degree and easily soluble, for therapeutic use against acquired immuno-deficiency syndromes | I F L O S A S DI GIORGIO E ALD (IT) | 1995-12-20 | — | — | EP | claimed |
| US-RE35631-E | Method of production of essentially pure melatonin and the method of solubilizing melatonin in water | IFLO S.A.S. (IT) | 1997-10-14 | — | — | US | disclosed |
| US-RE35631-E | Method of production of essentially pure melatonin and the method of solubilizing melatonin in water | IFLO S.A.S. (IT) | 1997-10-14 | — | — | US | disclosed |
| EP-0330625-B1 | Total synthesis method for making an indole structure derivative product class, of the triptamine type, in particular, melatonin or N-acetyl-5-methoxytriptamine type, having a high purity degree and easily soluble, for therapeutic use against acquired immuno-deficiency syndromes | I F L O S A S DI GIORGIO E ALD (IT) | 1995-12-20 | — | — | EP | disclosed |
| US-5122535-A | Mixing with adenosine; treating AIDS | IFLO S.A.S. (IT) | 1992-06-16 | — | — | US | disclosed |
| US-5122535-A | Mixing with adenosine; treating AIDS | IFLO S.A.S. (IT) | 1992-06-16 | — | — | US | disclosed |
| EP-0330625-A2 | Total synthesis method for making an indole structure derivative product class, of the triptamine type, in particular, melatonin or N-acetyl-5-methoxytriptamine type, having a high purity degree and easily soluble, for therapeutic use against acquired immuno-deficiency syndromes | I.F.L.O. S.a.s. di Giorgio e Aldo Laguzzi (IT) | 1989-08-30 | — | — | EP | disclosed |