Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.71 |
| ▸ | BCR | P11274 | 7/20 | 0.71 |
| ▸ | PRKCA | P17252 | 6/20 | 0.71 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 4/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.60 |
| ▸ | EGFR | P00533 | 2/20 | 0.60 |
| ▸ | PRKACA | P17612 | 2/20 | 0.60 |
| ▸ | PRKACG | P22612 | 2/20 | 0.60 |
| ▸ | PRKACB | P22694 | 2/20 | 0.60 |
| ▸ | SYK | P43405 | 5/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.56 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8837776 | 0.91 | ABL1 (0.70) | ABL1BCRPRKCACSNK2A1SRC | |
| SCHEMBL3509891 | 0.90 | ABL1 (0.74) | ABL1BCRPRKCACSNK2A1SRC | |
| SCHEMBL8837875 | 0.87 | ABL1 (0.78) | ABL1BCRPRKCACSNK2A1SRC | |
| SCHEMBL8837783 | 0.86 | CSNK2A1 (0.67) | ABL1BCRPRKCACSNK2A1SRC | |
| SCHEMBL8837795 | 0.86 | ABL1 (0.80) | ABL1BCRPRKCACSNK2A1SRC | |
| SCHEMBL1255 | 0.86 | ABL1 (0.80) | ABL1BCRPRKCACSNK2A1SRC | |
| SCHEMBL8837864 | 0.86 | ABL1 (0.62) | ABL1BCRPRKCACSNK2A1SRC | |
| SCHEMBL3511762 | 0.85 | ABL1 (0.73) | ABL1BCRPRKCACSNK2A1SRC | |
| SCHEMBL8837903 | 0.85 | PRKCA (0.83) | ABL1BCRPRKCACSNK2A1SRC | |
| SCHEMBL8837857 | 0.85 | ABL1 (0.76) | ABL1BCRPRKCACSNK2A1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5612340-A | ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-03-18 | — | — | US | claimed |
| US-5612340-A | ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-03-18 | — | — | US | disclosed |