Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | ESRRA | P11474 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | PTAFR | P25105 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8838406 | 0.93 | PTPN1 (0.43) | PTPN1PTPN2PTPN6PTPN11ESRRA | |
| SCHEMBL8838306 | 0.92 | THRA (0.46) | PTPN1PTPN2PTPN6PTPN11ESRRA | |
| SCHEMBL8838371 | 0.89 | TDP1 (0.44) | PTPN1PTPN2PTPN6PTPN11ESRRA | |
| SCHEMBL8838478 | 0.86 | KDM4E (0.41) | HTTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL8838315 | 0.82 | ALDH1A1 (0.36) | HTTHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL8838427 | 0.82 | MAPK1 (0.38) | LMNAHTTHSD17B10KDM4EALDH1A1 | |
| SCHEMBL8578814 | 0.81 | KDM4E (0.40) | HSD17B10KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8838534 | 0.81 | PPARG (0.34) | KDM4EALDH1A1HPGDMAPK1MAPT | |
| SCHEMBL3722730 | 0.80 | KDM4E (0.45) | HTTHSD17B10KDM4EALDH1A1GAA | |
| SCHEMBL8838524 | 0.80 | HDAC1 (0.36) | LMNAKDM4EALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700839-A | ANTIARRYTHMIA AGENTS; ACT AS INHIBITORS OF THE CELLULAR NA+/H+ ANTIPORTER | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-23 | — | — | US | disclosed |