Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 4/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | FRK | P42685 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8838524 | 0.90 | HDAC1 (0.36) | MAPK8MAPK9MAPK10PRKD3MAPK1 | |
| SCHEMBL8838379 | 0.88 | TAS1R3 (0.36) | KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL8838427 | 0.87 | MAPK1 (0.38) | MAPK8MAPK9MAPK10PRKD3MAPK1 | |
| SCHEMBL8838353 | 0.85 | CYP19A1 (0.35) | MAPK8MAPK9MAPK10PRKD3MAPK1 | |
| SCHEMBL8838478 | 0.83 | KDM4E (0.41) | MAPK8MAPK9MAPK10PRKD3MAPK1 | |
| SCHEMBL8441114 | 0.81 | SLC9A1 (0.48) | — | |
| SCHEMBL8838341 | 0.81 | PTPN1 (0.42) | MAPK1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL8838371 | 0.80 | TDP1 (0.44) | MAPK8MAPK9MAPK10PRKD3MAPK1 | |
| SCHEMBL8581801 | 0.80 | KDM4E (0.34) | KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL8838406 | 0.80 | PTPN1 (0.43) | KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700839-A | ANTIARRYTHMIA AGENTS; ACT AS INHIBITORS OF THE CELLULAR NA+/H+ ANTIPORTER | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-23 | — | — | US | disclosed |