Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8820335 | 0.85 | KCNMA1 (0.43) | MAPTALDH1A1MEN1KMT2ACASP1 | |
| SCHEMBL9834046 | 0.82 | MAPT (0.47) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8842309 | 0.81 | ALDH1A1 (0.38) | JAK3MAPTALDH1A1MEN1KMT2A | |
| Carbamic Acid SCHEMBL9261022 | 0.78 | ALDH1A1 (0.36) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8655676 | 0.77 | POLB (0.41) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8657521 | 0.77 | ABL1 (0.37) | JAK3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL8656564 | 0.77 | TDP1 (0.41) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL5259073 | 0.76 | MAPT (0.45) | MAPTALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL8654023 | 0.76 | ALDH1A1 (0.35) | JAK3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL27314727 | 0.75 | ALDH1A1 (0.37) | MAPTALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607959-A | ANALGESICS | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0683777-B1 | OXINDOLE 1-[N-(ALKOXYCARBONYL)]CARBOXAMIDES AND 1-[N-CARBOXAMIDO]CARBOXAMIDES AS INTIINFLAMMATORY AGENTS | PFIZER (US) | 1996-11-13 | — | — | EP | disclosed |
| EP-0683777-A1 | OXINDOLE 1- N-(ALKOXYCARBONYL)]CARBOXAMIDES AND 1-(N-CARBOXAMIDO)CARBOXAMIDES AS INTIINFLAMMATORY AGENTS. | PFIZER (US) | 1995-11-29 | — | — | EP | disclosed |
| WO-1994018194-A1 | OXINDOLE 1-[N-(ALKOXYCARBONYL)]CARBOXAMIDES AND 1-(N-CARBOXAMIDO)CARBOXAMIDES AS INTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1994-08-18 | — | — | WO | disclosed |
| EP-0276500-B1 | 2-OXINDOLE INTERMEDIATES | PFIZER INC. (US) | 1991-05-15 | — | — | EP | disclosed |
| CN-1009197-B | Process for preparing N, 3-disubstituted 2-oxindole-1-carboxamides | PFIZER (US) | 1990-08-15 | — | — | CN | disclosed |
| EP-0164860-B1 | N,3-DISUBSTITUTED 2-OXINDOLE-1-CARBOXAMIDES AS ANALGESIC AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1989-07-05 | — | — | EP | disclosed |
| EP-0175551-B1 | ANALGESIC AND ANTIINFLAMMATORY 1,3-DIACYL-2-OXINDOLE COMPOUNDS | PFIZER INC. (US) | 1989-05-10 | — | — | EP | disclosed |
| EP-0153818-B1 | 1,3-DISUBSTITUTED 2-OXINDOLES AS ANALGESIC AND ANTI-INFLAMMATORY AGENTS | PFIZER INC. (US) | 1989-03-15 | — | — | EP | disclosed |
| US-4808601-A | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds | PFIZER INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0276500-A2 | 2-Oxindole intermediates | PFIZER INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4752609-A | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds | PFIZER INC. (US) | 1988-06-21 | — | — | US | disclosed |
| US-4690943-A | ENZYME INHIBITOR OF CYCLOOXYGENASE AND LIPOXYGENASE | PFIZER INC. (US) | 1987-09-01 | — | — | US | disclosed |
| US-4658037-A | RHEUMATIC DISEASES | PFIZER INC. (US) | 1987-04-14 | — | — | US | disclosed |
| CN-85103527-A | Preparation N, the method for the disubstituted 2-hydroxyindole of 3--1-hydroxyalkyl cooh amide | — | 1987-01-28 | — | — | CN | disclosed |
| EP-0175551-A1 | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds | PFIZER INC. (US) | 1986-03-26 | — | — | EP | disclosed |
| US-4569942-A | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | PFIZER INC. (US) | 1986-02-11 | — | — | US | disclosed |
| EP-0164860-A1 | N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | PFIZER INC. (US) | 1985-12-18 | — | — | EP | disclosed |
| EP-0153818-A2 | 1,3-Disubstituted 2-oxindoles as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-09-04 | — | — | EP | disclosed |