Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739849 | 0.81 | MAPT (0.44) | MAPTHTR7DRD2DRD1HTR2A | |
| SCHEMBL4850477 | 0.81 | MAPT (0.44) | MAPTHTR7DRD2DRD1HTR2A | |
| SCHEMBL10545893 | 0.79 | TP53 (0.47) | MAPTHTR7DRD2DRD1HTR2A | |
| SCHEMBL8138050 | 0.76 | HTR7 (0.48) | HTR7DRD2DRD1HTR2AHTR2C | |
| SCHEMBL8841799 | 0.76 | JAK3 (0.41) | MAPTKMT2ATP53MEN1ALDH1A1 | |
| SCHEMBL8842076 | 0.76 | MAPT (0.40) | MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL1461839 | 0.75 | MAPT (0.56) | MAPTKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL24112727 | 0.74 | PGR (0.53) | HTR7DRD2DRD1HTR2AHTR2C | |
| SCHEMBL2263637 | 0.74 | PGR (0.53) | HTR7DRD2DRD1HTR2AHTR2C | |
| SCHEMBL3912643 | 0.73 | ALDH1A1 (0.63) | MAPTKMT2ATP53MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342040-B2 | 5-fluorooxindole-3-carboxylic acid ester | UBE INDUSTRIES, LTD. (JP) | 2008-03-11 | — | — | US | disclosed |
| EP-1592426-B1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2007-12-19 | — | — | EP | disclosed |