Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | DRD3 | P35462 | 7/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8842065 | 0.89 | ACHE (0.59) | CYP2D6TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9122282 | 0.81 | ACHE (0.55) | ACHEDRD2 | |
| SCHEMBL8842402 | 0.81 | SIGMAR1 (0.52) | CYP2D6ACHEDRD2DRD3CYP1A2 | |
| SCHEMBL18408089 | 0.74 | ACHE (0.42) | CYP2D6SLC6A2SLC6A4SLC6A3ACHE | |
| SCHEMBL8842343 | 0.69 | ACHE (0.67) | ACHEDRD2OPRM1 | |
| SCHEMBL9557986 | 0.69 | CYP2D6 (0.79) | CYP2D6TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16408562 | 0.68 | ACHE (0.52) | ACHEALDH1A1 | |
| SCHEMBL15938228 | 0.68 | CYP2D6 (1.00) | CYP2D6TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7433038 | 0.68 | CYP2D6 (1.00) | CYP2D6TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22772662 | 0.68 | CYP2D6 (1.00) | CYP2D6TSHRSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594002-A | Benzazabicyclic carbamates as novel cholinesterase inhibitors | PFIZER INC (US) | 1997-01-14 | — | — | US | disclosed |
| US-5387590-A | Benzazabicyclic carbamates as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-02-07 | — | — | US | disclosed |
| WO-1991003467-A1 | BENZAZABICYCLIC CARBAMATES AS NOVEL CHOLINESTERASE INHIBITORS | PFIZER INC. (US) | 1991-03-21 | — | — | WO | disclosed |
| EP-0415634-A2 | Benzazabicyclic carbamates as cholinesterase inhibitors | PFIZER INC. (US) | 1991-03-06 | — | — | EP | disclosed |