Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8841972 | 0.81 | CYP2D6 (0.51) | ACHEOPRM1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8842065 | 0.80 | ACHE (0.59) | ACHECHRNB2CHRNA4CYP2D6DRD2 | |
| SCHEMBL18408089 | 0.80 | ACHE (0.42) | SIGMAR1ACHECHRNB2CHRNA4OPRM1 | |
| SCHEMBL8842766 | 0.78 | ACHE (0.54) | SIGMAR1ACHEOPRM1OPRD1DRD2 | |
| SCHEMBL18099210 | 0.78 | SIGMAR1 (0.59) | SIGMAR1ACHECHRNB2CHRNA4DRD2 | |
| SCHEMBL18099323 | 0.75 | SIGMAR1 (0.74) | SIGMAR1ACHECHRNB2CHRNA4DRD2 | |
| SCHEMBL20245626 | 0.74 | OPRM1 (0.42) | SIGMAR1OPRM1OPRD1OPRK1CYP1A2 | |
| SCHEMBL9549900 | 0.74 | KDM4E (0.39) | SIGMAR1ACHECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6995541 | 0.73 | CHRNB2 (0.68) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL12159209 | 0.72 | SIGMAR1 (0.38) | SIGMAR1CHRNB2CHRNA4OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594002-A | Benzazabicyclic carbamates as novel cholinesterase inhibitors | PFIZER INC (US) | 1997-01-14 | — | — | US | disclosed |
| US-5387590-A | Benzazabicyclic carbamates as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-02-07 | — | — | US | disclosed |
| WO-1991003467-A1 | BENZAZABICYCLIC CARBAMATES AS NOVEL CHOLINESTERASE INHIBITORS | PFIZER INC. (US) | 1991-03-21 | — | — | WO | disclosed |
| EP-0415634-A2 | Benzazabicyclic carbamates as cholinesterase inhibitors | PFIZER INC. (US) | 1991-03-06 | — | — | EP | disclosed |