Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 3/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.31 |
| ▸ | CCKBR | P32239 | 2/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | CCKAR | P32238 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.30 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9264467 | 0.89 | MDM2 (0.34) | MDM2SCN9ACCKBRPDCD1CD274 | |
| SCHEMBL7321486 | 0.88 | HDAC1 (0.38) | MDM2DRD2 | |
| SCHEMBL7328784 | 0.86 | MDM2 (0.34) | MDM2SCN9ACCKBRCCKARRIPK1 | |
| SCHEMBL8842761 | 0.85 | PDCD1 (0.31) | MDM2PDCD1CD274 | |
| SCHEMBL7326347 | 0.83 | TPSAB1 (0.37) | SCN9ACCKBRPDCD1CD274DRD2 | |
| SCHEMBL9493013 | 0.82 | PDCD1 (0.37) | MDM2SCN9ACCKBRPDCD1CD274 | |
| SCHEMBL9262540 | 0.82 | SCN9A (0.34) | MDM2SCN9ACCKBRPDCD1CD274 | |
| SCHEMBL7326230 | 0.81 | HDAC1 (0.37) | MDM2SCN9A | |
| SCHEMBL7329948 | 0.81 | MDM2 (0.33) | MDM2SCN9AGABRA1GABRG2GABRB3 | |
| SCHEMBL7330839 | 0.81 | ADORA3 (0.34) | MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663166-A | ANTICOAGULANTS OF 1,4-BENZODIAZEPINE-2,5-DIONE AND 2-BENZOAZEPINE-1,4-DIONE DERIVATIVES; PREVENTS FIBRINOGEN BINDING NECESSARY FOR PLATELET AGGREGATION; SIDE EFFECT REDUCTION, E.G. EXCESSIVE BLEEDING | GENENTECH, INC. (US) | 1997-09-02 | — | — | US | disclosed |