Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8843322 | 0.85 | ANPEP (0.48) | HDAC3HDAC1HDAC2HDAC8L3MBTL1 | |
| SCHEMBL8843418 | 0.76 | KDM4E (0.58) | HPGDTSHRKDM4EALDH1A1MEN1 | |
| SCHEMBL172622 | 0.75 | LMNA (0.63) | LMNAHPGDNPC1L3MBTL1MAPK1 | |
| SCHEMBL27581999 | 0.74 | LMNA (0.53) | LMNAHPGDTSHRNPC1L3MBTL1 | |
| SCHEMBL27599234 | 0.74 | LMNA (0.53) | LMNAHPGDTSHRNPC1L3MBTL1 | |
| SCHEMBL5798369 | 0.74 | MAPT (0.54) | LMNAHPGDNPC1KDM4EALDH1A1 | |
| SCHEMBL13330952 | 0.73 | LMNA (0.60) | LMNAHPGDNPC1L3MBTL1MAPK1 | |
| SCHEMBL3705685 | 0.73 | SCN3A (0.55) | LMNADPP4HDAC3HDAC1HDAC2 | |
| SCHEMBL8843532 | 0.73 | FOLH1 (0.49) | HDAC3HDAC1HDAC2HDAC8L3MBTL1 | |
| SCHEMBL2247510 | 0.72 | FOLH1 (0.49) | LMNAMAPK1ALDH1A1FOLH1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5672615-A | MATRIX-DEGRADING METALLOPROTEINASE INHIBITORS | NOVARTIS CORPORATION (US) | 1997-09-30 | — | — | US | disclosed |