Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL170986 | 0.82 | LMNA (0.64) | LMNAL3MBTL1CHRM2NPC1HPGD | |
| SCHEMBL21799751 | 0.81 | ANPEP (0.50) | LMNAL3MBTL1CYP2D6ALDH1A1 | |
| SCHEMBL24762812 | 0.81 | MEN1 (0.50) | CHRM2DNM1CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL12923898 | 0.81 | MEN1 (0.50) | CHRM2DNM1CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL13330952 | 0.79 | LMNA (0.60) | LMNAL3MBTL1CHRM2NPC1HPGD | |
| SCHEMBL13995701 | 0.79 | LMNA (0.60) | LMNAL3MBTL1CHRM2NPC1HPGD | |
| SCHEMBL172355 | 0.79 | SLC6A4 (0.49) | NPC1CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL15163968 | 0.78 | LMNA (1.00) | LMNAL3MBTL1CHRM2MAPK1CYP3A4 | |
| SCHEMBL172367 | 0.78 | LMNA (0.44) | LMNAMAPK1CYP3A4ALDH1A1MEN1 | |
| SCHEMBL172625 | 0.77 | LOXL2 (0.55) | LMNAHPGDCYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255738-B1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES INC (US) | 2012-03-07 | — | — | EP | disclosed |