Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.63 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8581527 | 0.94 | PDE4A (0.63) | PDE4ACYP1A1CYP1A2HSD17B10KDM4E | |
| SCHEMBL8844119 | 0.85 | KDM4E (0.67) | PDE4ACYP1A1CYP1A2HSD17B10KDM4E | |
| SCHEMBL8063237 | 0.79 | CYP1A1 (0.69) | CYP1A1CYP1A2HSD17B10KDM4EALDH1A1 | |
| SCHEMBL8843771 | 0.79 | PDE4A (0.52) | PDE4ACYP1A1CYP1A2HSD17B10KDM4E | |
| SCHEMBL12303132 | 0.78 | KDM4E (0.60) | CYP1A2HSD17B10KDM4EALDH1A1TSHR | |
| SCHEMBL8844461 | 0.78 | HSD17B10 (0.48) | PDE4ACYP1A1CYP1A2HSD17B10KDM4E | |
| SCHEMBL4649969 | 0.78 | ABCB1 (0.73) | CYP1A1CYP1A2ALDH1A1KMT2AABCB1 | |
| SCHEMBL8052929 | 0.78 | ABCB1 (0.69) | CYP1A1CYP1A2ALDH1A1KMT2AABCB1 | |
| SCHEMBL8066758 | 0.78 | L3MBTL1 (0.72) | CYP1A1CYP1A2HSD17B10KDM4EALDH1A1 | |
| SCHEMBL31022791 | 0.77 | CYP1A1 (0.72) | CYP1A1CYP1A2HSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5629340-A | DIPHENYL FURAN COMPOUNDS | TSUMURA & CO. (JP) | 1997-05-13 | — | — | US | disclosed |
| EP-0678296-A1 | VASCULARIZATION INHIBITOR AND NOVEL COMPOUND | TSUMURA & CO. (JP) | 1995-10-25 | — | — | EP | disclosed |