Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 4/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9116224 | 0.86 | GRM8 (0.49) | GRM8GRM4KCNA5KCNN4SMN1; SMN2 | |
| SCHEMBL8843523 | 0.80 | GRM8 (0.43) | GRM8GRM4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12698775 | 0.77 | SMN1; SMN2 (0.50) | KCNA5SMN1; SMN2CFTRSLC6A2SLC6A4 | |
| SCHEMBL8461518 | 0.75 | KCNA5 (0.47) | GRM8GRM4KCNA5KCNN4SMN1; SMN2 | |
| SCHEMBL17047114 | 0.74 | TBXAS1 (0.49) | GRM8GRM4KCNA5SMN1; SMN2CFTR | |
| SCHEMBL17546168 | 0.73 | SMN1; SMN2 (0.50) | KCNA5KCNN4SMN1; SMN2CFTRSLC6A2 | |
| SCHEMBL5666093 | 0.73 | PGK1 (0.57) | GRM8GRM4KCNA5KCNN4SMN1; SMN2 | |
| SCHEMBL5060253 | 0.73 | GRM8 (0.46) | GRM8GRM4KCNA5KCNN4SMN1; SMN2 | |
| SCHEMBL6505819 | 0.72 | SMN1; SMN2 (0.58) | GRM8GRM4KCNA5KCNN4SMN1; SMN2 | |
| SCHEMBL8843099 | 0.72 | ACP3 (0.58) | CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627170-A | Phosphonic acid compound containing heterocyclic substituents, pharmaceutical composition contains same and a method of treating calcium metabolism disturbance | BOEHRINGER MANNHEIM GMBH (DE) | 1997-05-06 | — | — | US | disclosed |
| US-5538957-A | OSTEOPOROSIS | BOEHRINGER MANNHEIM GMBH (DE) | 1996-07-23 | — | — | US | disclosed |
| CN-1088931-A | New phosphonosuccinic acid derivatives and preparation method thereof and the pharmaceutical composition that contains these compounds | BOEHRINGER MANNHEIM GMBH (DE) | 1994-07-06 | — | — | CN | disclosed |