Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 8/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5038360 | 0.91 | KCNA5 (0.48) | KCNA5KCNH2GRM2ALDH1A1CYP3A4 | |
| SCHEMBL884639 | 0.89 | KCNA5 (0.45) | KCNA5KCNH2GRM2ALDH1A1CYP3A4 | |
| SCHEMBL5033715 | 0.88 | KCNA5 (0.50) | KCNA5KCNH2GRM2ALDH1A1CYP3A4 | |
| SCHEMBL5032466 | 0.87 | KCNA5 (0.45) | KCNA5KCNH2GRM2ALDH1A1 | |
| SCHEMBL884569 | 0.87 | KCNA5 (0.51) | KCNA5KCNH2GRM2ALDH1A1 | |
| SCHEMBL885069 | 0.85 | KCNA5 (0.56) | KCNA5KCNH2GRM2ALDH1A1CYP3A4 | |
| SCHEMBL2063347 | 0.84 | KCNA5 (0.62) | KCNA5KCNH2GRM2ADRB3ADRB1 | |
| SCHEMBL884457 | 0.83 | KCNA5 (0.51) | KCNA5KCNH2ALDH1A1CYP3A4 | |
| SCHEMBL884595 | 0.83 | KCNA5 (0.45) | KCNA5KCNH2GRM2ALDH1A1 | |
| SCHEMBL884718 | 0.81 | KCNA5 (0.51) | KCNA5KCNH2GRM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |