Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL884639 | 0.85 | KCNA5 (0.45) | KCNA5ALDH1A1KCNH2CYP11B1CYP11B2 | |
| SCHEMBL884569 | 0.85 | KCNA5 (0.51) | KCNA5ALDH1A1KCNH2CYP11B1CYP11B2 | |
| SCHEMBL5038360 | 0.85 | KCNA5 (0.48) | KCNA5ALDH1A1KCNH2CYP11B1CYP11B2 | |
| SCHEMBL5033715 | 0.84 | KCNA5 (0.50) | KCNA5ALDH1A1KCNH2CYP11B1CYP11B2 | |
| SCHEMBL884817 | 0.84 | PDE4A (0.46) | KCNA5ALDH1A1KCNH2CYP11B1CYP11B2 | |
| SCHEMBL884457 | 0.84 | KCNA5 (0.51) | KCNA5ALDH1A1KCNH2CYP11B1CYP11B2 | |
| SCHEMBL885203 | 0.83 | KCNA5 (0.42) | KCNA5ALDH1A1KCNH2CYP11B1CYP11B2 | |
| SCHEMBL884449 | 0.81 | KCNA5 (0.44) | KCNA5ALDH1A1KCNH2GRM2 | |
| SCHEMBL2062680 | 0.81 | KCNA5 (0.60) | KCNA5ALDH1A1KCNH2GRM5 | |
| SCHEMBL884634 | 0.81 | CYP3A4 (0.45) | KCNA5ALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |