Toluene

Toluene

SCHEMBL8844853

CC(C)Cl.Cc1ccccc1

nearest known ligand 0.73

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 4/20 0.73
TSHR P16473 4/20 0.73
LMNA P02545 4/20 0.73
ALOX12 P18054 1/20 0.73
TDP1 Q9NUW8 3/20 0.44
HPGD P15428 2/20 0.43
CES2 O00748 1/20 0.40
CES1 P23141 1/20 0.40
POLB P06746 1/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
NPSR1 Q6W5P4 2/20 0.39
ALDH1A1 P00352 3/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
XBP1 P17861 1/20 0.38
HTT P42858 1/20 0.38
ATM Q13315 1/20 0.38
TP53 P04637 1/20 0.38
KDM4E B2RXH2 2/20 0.37
MAPT P10636 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Toluene SCHEMBL607202 0.97 TSHR (0.69) ACHETSHRLMNAALOX12TDP1
Toluene SCHEMBL28398458 0.93 ACHE (0.73) ACHETSHRLMNAALOX12TDP1
Toluene SCHEMBL87982 0.93 ACHE (0.73) ACHETSHRLMNAALOX12TDP1
Toluene SCHEMBL6242293 0.90 ACHE (0.69) ACHETSHRLMNAALOX12TDP1
Toluene SCHEMBL266608 0.88 LMNA (0.65) ACHETSHRLMNAALOX12TDP1
Toluene SCHEMBL10396121 0.88 ACHE (0.65) ACHETSHRLMNAALOX12TDP1
Toluene SCHEMBL5141031 0.86
Toluene SCHEMBL10989418 0.86
SCHEMBL12344943 0.86 ACHE (1.00) ACHETSHRLMNAALOX12TDP1
Toluene SCHEMBL175861 0.86 ACHE (1.00) ACHETSHRLMNAALOX12TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111051295-B Heterocyclic compounds and their use 武田药品工业株式会社 2022-09-02 CN disclosed
CN-113402389-A Preparation method for synthesizing isopropyl chloride by reacting isopropanol with phosgene 上海祖玥新材料科技有限公司 2021-09-17 CN disclosed
CN-111051295-A Heterocyclic compounds and their use 武田药品工业株式会社 2020-04-21 CN disclosed
US-5668232-A Process for the production of polyisoolefins BAYER AG (DE) 1997-09-16 US disclosed