Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.73 |
| ▸ | MEN1 | O00255 | 5/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 4/20 | 0.72 |
| ▸ | RAB9A | P51151 | 3/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | MGLL | Q99685 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | FAAH | O00519 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8845496 | 0.98 | ALDH1A1 (0.77) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL5653225 | 0.98 | ALDH1A1 (0.77) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL1578826 | 0.93 | ALDH1A1 (0.78) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL11480252 | 0.91 | ALDH1A1 (0.81) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL6882525 | 0.91 | ALDH1A1 (0.81) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL3077817 | 0.89 | SMN1; SMN2 (0.72) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL8844997 | 0.85 | NPC1 (0.67) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL8844777 | 0.85 | NPC1 (0.67) | KMT2AMEN1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL5649217 | 0.85 | HSD17B10 (0.81) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL11882343 | 0.85 | MGLL (0.72) | KMT2AMEN1SMN1; SMN2LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0428385-A1 | Cholesterol ester hydrolase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-22 | — | — | EP | claimed |
| US-5602151-A | ADMINISTERING TO MAMMALS TO REDUCE SERUM CHOLESTEROL LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-11 | — | — | US | disclosed |
| US-5512565-A | REDUCE CHOLESTEROL ABSORPTION IN MAMMALS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-04-30 | — | — | US | disclosed |
| US-5391571-A | Cholesterol ester hydrolase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-02-21 | — | — | US | disclosed |
| EP-0428385-A1 | Cholesterol ester hydrolase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-22 | — | — | EP | disclosed |