⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2689529 | 0.66 | — | — | |
| SCHEMBL4348682 | 0.57 | — | — | |
| SCHEMBL3266009 | 0.57 | — | — | |
| SCHEMBL910100 | 0.55 | — | — | |
| SCHEMBL19364499 | 0.55 | PTPN1 (0.33) | — | |
| SCHEMBL15658193 | 0.54 | — | — | |
| SCHEMBL1567354 | 0.54 | TSHR (0.35) | — | |
| SCHEMBL4520016 | 0.53 | TP53 (0.38) | — | |
| SCHEMBL13629585 | 0.53 | TP53 (0.38) | — | |
| SCHEMBL15835005 | 0.53 | PGR (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10646555-B2 | Compositions and methods relating to argininosuccinate synthetase | BIOREGENCY, INC. (US) | 2020-05-12 | — | — | US | disclosed |
| EP-2531224-B1 | COMPOSITIONS AND METHODS RELATING TO ARGININOSUCCINATE SYNTHETASE | BIOREGENCY INC (US) | 2019-06-05 | — | — | EP | disclosed |
| US-20170281738-A1 | COMPOSITIONS AND METHODS RELATING TO ARGININOSUCCINATE SYNTHETASE | BIOREGENCY INC. | 2017-10-05 | — | — | US | disclosed |
| US-9682132-B2 | Compositions and methods relating to argininosucccinate synthetase | BANYAN BIOMARKERS, INC (US) | 2017-06-20 | — | — | US | disclosed |
| US-20140178351-A1 | COMPOSITIONS AND METHODS RELATING TO ARGININOSUCCCINATE SYNTHETASE | BIOREGENCY INC. | 2014-06-26 | — | — | US | disclosed |
| EP-2531224-A2 | COMPOSITIONS AND METHODS RELATING TO ARGININOSUCCINATE SYNTHETASE | Banyan Biomarkers, Inc. (US) | 2012-12-12 | — | — | EP | disclosed |
| WO-2012141674-A2 | COMPOSITIONS AND METHODS RELATING TO ARGININOSUCCINATE SYNTHETASE | BANYAN BIOMARKERS, INC. (US) | 2012-10-18 | — | — | WO | disclosed |
| US-5616585-A | Pyridopyrazine derivatives for treating alcohol and nicotine abuse and addiction | PFIZER INC. (US) | 1997-04-01 | — | — | US | disclosed |
| EP-0536173-B1 | PYRIDOPYRAZINE DERIVATIVES FOR TREATING SUBSTANCE ABUSE AND ADDICTION | PFIZER (US) | 1995-01-04 | — | — | EP | disclosed |
| EP-0536173-A1 | PYRIDOPYRAZINE DERIVATIVES FOR TREATING SUBSTANCE ABUSE AND ADDICTION. | PFIZER (US) | 1993-04-14 | — | — | EP | disclosed |
| EP-0380217-B1 | BIS-AZA-BICYCLIC ANXIOLYTIC AGENTS AND ANTIDEPRESSANTS | PFIZER INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5122525-A | Bis-aza-bicyclic anxiolytic agents | PFIZER INC. (US) | 1992-06-16 | — | — | US | disclosed |
| WO-1992000075-A1 | PYRIDOPYRAZINE DERIVATIVES FOR TREATING SUBSTANCE ABUSE AND ADDICTION | PFIZER INC. (US) | 1992-01-09 | — | — | WO | disclosed |
| EP-0380217-A1 | Bis-aza-bicyclic anxiolytic agents and antidepressants | PFIZER INC. (US) | 1990-08-01 | — | — | EP | disclosed |
| WO-1990008148-A1 | BIS-AZA-BICYCLIC ANXIOLYTIC AGENTS | PFIZER INC. (US) | 1990-07-26 | — | — | WO | disclosed |
| WO-1990008144-A1 | BIS-AZA-BICYCLIC ANXIOLYTIC AGENTS | PFIZER INC. (US) | 1990-07-26 | — | — | WO | disclosed |