Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | DBH | P09172 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
| ▸ | PTPRF | P10586 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8845309 | 0.95 | MAPT (0.46) | CYP19A1MAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8845468 | 0.94 | CYP19A1 (0.40) | CYP19A1KDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL8845463 | 0.94 | KCNJ1 (0.44) | CYP19A1MAPTSMN1; SMN2ALDH1A1KCNJ1 | |
| SCHEMBL8845405 | 0.94 | SLC29A1 (0.40) | CYP19A1KDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL8845438 | 0.94 | SMN1; SMN2 (0.44) | CYP19A1KDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL8845932 | 0.94 | BCHE (0.45) | KDM4EMAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8845454 | 0.91 | TGM2 (0.46) | CYP19A1KDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL8845246 | 0.91 | KCNJ1 (0.47) | MAPTLMNASMN1; SMN2ALDH1A1KCNJ1 | |
| SCHEMBL8845414 | 0.91 | KCNJ1 (0.47) | CYP19A1KDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL8845195 | 0.84 | POLB (0.37) | CYP19A1KDM4EMAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674886-A | AROMATASE INHIBITOR; BREAST CANCER; UROGENITAL DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-07 | — | — | US | disclosed |