Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8845678 | 1.00 | MAPT (0.55) | MAPTALDH1A1KDM4EHPGDTRPA1 | |
| SCHEMBL8916304 | 0.93 | ALDH1A1 (0.55) | MAPTALDH1A1KDM4EHPGDTRPA1 | |
| SCHEMBL8916301 | 0.93 | ALDH1A1 (0.55) | MAPTALDH1A1KDM4EHPGDTRPA1 | |
| SCHEMBL13579994 | 0.91 | KDM4E (0.66) | MAPTALDH1A1KDM4EHPGDCYP3A4 | |
| SCHEMBL7336089 | 0.85 | PLAU (0.59) | ALDH1A1KDM4ETRPA1CYP3A4NFKB1 | |
| SCHEMBL7343141 | 0.85 | PLAU (0.59) | ALDH1A1KDM4ETRPA1CYP3A4NFKB1 | |
| SCHEMBL4465918 | 0.83 | MAPT (0.56) | MAPTALDH1A1KDM4EHPGDCYP3A4 | |
| SCHEMBL4465915 | 0.83 | MAPT (0.56) | MAPTALDH1A1KDM4EHPGDCYP3A4 | |
| SCHEMBL6065194 | 0.80 | PLAU (0.50) | MAPTALDH1A1KDM4EHPGDTRPA1 | |
| SCHEMBL6065195 | 0.80 | PLAU (0.50) | MAPTALDH1A1KDM4EHPGDTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663207-A | ADMINISTERING TO INHIBIT DEVELOPMENT OF BREAST TUMOR | RESEARCH CORPORATION TECHNOLOGIES (US) | 1997-09-02 | — | — | US | disclosed |
| US-5658914-A | ANTIESTROGENS, ANTITUMOR AGENTS | RESEARCH CORPORATION TECHNOLOGIES (US) | 1997-08-19 | — | — | US | disclosed |
| US-5658951-A | ANTIESTROGENS, ANTITUMOR AGENTS | RESEARCH CORPORATION TECHNOLOGIES (US) | 1997-08-19 | — | — | US | disclosed |
| US-5658927-A | ANTIESTROGENS, ANTITUMOR AGENTS | RESEARCH CORPORATION TECHNOLOGIES (US) | 1997-08-19 | — | — | US | disclosed |
| US-5397802-A | Gem-dichlorocyclopropanes as antitumor agents | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1995-03-14 | — | — | US | disclosed |
| US-4879315-A | Cyclopropyl analogs as anti-estrogenic, anti-tumor and female fertility agents | THE BOARD OF REGENTS FOR THE UNIVERSITY OF OKLAHOMA (US) | 1989-11-07 | — | — | US | disclosed |