Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.44 |
| ▸ | CCND1 | P24385 | 4/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502783 | 0.83 | ITGB3 (0.48) | CDK4CCND1HRH1CYP24A1ITGB3 | |
| SCHEMBL14274529 | 0.78 | MCL1 (0.44) | ITGB3ITGAVITGB5 | |
| SCHEMBL8845775 | 0.78 | PLG (0.45) | CDK4CCND1PLGPLAUHRH1 | |
| SCHEMBL8845546 | 0.78 | ITGB3 (0.48) | ITGB3ITGAVITGB5 | |
| SCHEMBL14300254 | 0.77 | ITGB3 (0.45) | ITGB3ITGAVITGB5CYP19A1CYP1A2 | |
| SCHEMBL8845730 | 0.75 | ITGB3 (0.47) | ITGB3ITGAVITGB5 | |
| SCHEMBL12542891 | 0.74 | CDK4 (0.59) | CDK4CCND1HRH1HTT | |
| SCHEMBL8845545 | 0.73 | ITGB3 (0.44) | ITGB3ITGAVITGB5 | |
| SCHEMBL17602180 | 0.73 | RORC (0.47) | CDK4CCND1CYP19A1BACE1ESRRG | |
| SCHEMBL21245279 | 0.73 | PLG (0.54) | CDK4CCND1PLGPLAUCYP24A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688816-A | COGNITION ACTIVATOR; ALZHEIMER'S DISEASE | HOECHST MARION ROUSSEL, INC. (US) | 1997-11-18 | — | — | US | disclosed |