Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 3/20 | 0.53 |
| ▸ | PLA2G4B | P0C869 | 7/20 | 0.50 |
| ▸ | RARB | P10826 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8845974 | 0.92 | PLA2G4B (0.46) | PTPN11PLA2G4BPTGER1 | |
| SCHEMBL8845849 | 0.89 | PTPN11 (0.52) | PTPN11PTGER1 | |
| SCHEMBL8845537 | 0.81 | PTPN11 (0.43) | PTPN11PTGER1 | |
| SCHEMBL8846106 | 0.79 | LTB4R (0.56) | PTPN11PTGER1 | |
| SCHEMBL8845966 | 0.78 | CFD (0.46) | RARBTP53PTGER1 | |
| SCHEMBL8845944 | 0.77 | PTPN11 (0.63) | PTPN11PLA2G4BPTGER1 | |
| SCHEMBL8846113 | 0.76 | PTPN11 (0.61) | PTPN11PLA2G4BPTGER1 | |
| SCHEMBL28136287 | 0.74 | TP53 (0.62) | PLA2G4BRARBTP53TSHR | |
| SCHEMBL8943435 | 0.74 | TP53 (0.82) | PLA2G4BRARBTP53TSHR | |
| SCHEMBL9664886 | 0.74 | TP53 (0.82) | PLA2G4BRARBTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664282-B1 | Biaryl phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-10-22 | — | — | EP | claimed |
| EP-0664282-A1 | Biaryl phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-26 | — | — | EP | claimed |
| US-5391817-A | Antiinflammatory agents | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | claimed |
| EP-0664282-B1 | Biaryl phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-10-22 | — | — | EP | disclosed |
| EP-0664282-A1 | Biaryl phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-26 | — | — | EP | disclosed |
| US-5391817-A | Antiinflammatory agents | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | disclosed |