Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8848171 | 0.85 | CTSK (0.47) | ALDH1A1HCAR2MAPK1L3MBTL1TDP1 | |
| SCHEMBL7558758 | 0.83 | CTSK (0.50) | ALDH1A1KMT2ALMNA | |
| SCHEMBL16809085 | 0.83 | ALDH1A1 (0.53) | ALDH1A1HCAR2MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL16805831 | 0.81 | ALDH1A1 (0.51) | ALDH1A1HCAR2MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL8773535 | 0.80 | ALDH1A1 (0.58) | ALDH1A1HCAR2MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL24297824 | 0.80 | ALDH1A1 (0.53) | ALDH1A1HCAR2MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL28973567 | 0.80 | ALDH1A1 (0.53) | ALDH1A1HCAR2MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL10645330 | 0.79 | ALDH1A1 (0.56) | ALDH1A1HCAR2MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL10645335 | 0.79 | ALDH1A1 (0.56) | ALDH1A1HCAR2MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL8847568 | 0.79 | ALDH1A1 (0.49) | ALDH1A1HCAR2MAPK1L3MBTL1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5482948-A | Pyridyl derivatives and pharmaceutical compositions comprising these compounds | DR. KARL THOMAE GMBH (DE) | 1996-01-09 | — | — | US | disclosed |
| US-5459147-A | Angeotensin-antagonistic effects; hypotensive, antiischemic, and antidiabetic agents, treating glaucoma | DR. KARL THOMAE GMBH (DE) | 1995-10-17 | — | — | US | disclosed |