Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3650795 | 0.81 | OPRM1 (0.51) | OPRM1OPRD1OPRK1TAAR1NPC1 | |
| SCHEMBL29145670 | 0.77 | TAAR1 (0.47) | OPRM1OPRD1OPRK1TAAR1SMN1; SMN2 | |
| SCHEMBL7516052 | 0.76 | KDM4E (0.56) | OPRM1OPRD1OPRK1TAAR1NPC1 | |
| SCHEMBL9373709 | 0.76 | TAAR1 (0.50) | OPRM1OPRD1OPRK1TAAR1HDAC1 | |
| SCHEMBL9373643 | 0.76 | — | — | |
| SCHEMBL2983737 | 0.75 | GRM5 (0.57) | OPRM1OPRD1OPRK1NPC1RAB9A | |
| SCHEMBL159163 | 0.74 | NPC1 (0.76) | TAAR1NPC1RAB9ASMN1; SMN2CA12 | |
| SCHEMBL28121189 | 0.74 | MTNR1A (0.50) | OPRM1OPRD1OPRK1TAAR1GAA | |
| SCHEMBL28110 | 0.73 | — | — | |
| SCHEMBL18381215 | 0.73 | SMN1; SMN2 (0.56) | OPRM1OPRD1OPRK1TAAR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637731-A | CHOLINERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-10 | — | — | US | disclosed |
| US-5550257-A | TREATING CENTRAL CHOLINERGIC DYSFUNCTION | AMERICAN CYANAMID COMPANY (US) | 1996-08-27 | — | — | US | disclosed |