Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 6/20 | 0.39 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8847495 | 0.86 | CHRM1 (0.39) | CA2CA1FDPS | |
| SCHEMBL20489978 | 0.79 | CA2 (0.41) | CA2MAPK1CA1SLC15A1FDPS | |
| SCHEMBL406135 | 0.79 | CA2 (0.52) | CA2MAPK1CA1ACE2GPR84 | |
| SCHEMBL3127227 | 0.79 | CA2 (0.41) | CA2MAPK1CA1SLC15A1FDPS | |
| SCHEMBL7316786 | 0.77 | CA2 (0.54) | CA2MAPK1CA1SLC15A1FDPS | |
| SCHEMBL7325930 | 0.77 | CA2 (0.54) | CA2MAPK1CA1SLC15A1FDPS | |
| SCHEMBL9831486 | 0.77 | CA2 (0.54) | CA2MAPK1CA1SLC15A1FDPS | |
| SCHEMBL277109 | 0.76 | — | — | |
| SCHEMBL275962 | 0.75 | — | — | |
| SCHEMBL11458224 | 0.74 | CA2 (0.38) | CA2MAPK1CA1SLC15A1FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |