Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24200475 | 0.77 | GAA (0.38) | MEN1GAAKMT2ASMN1; SMN2TRPM8 | |
| SCHEMBL19441166 | 0.71 | GAA (0.39) | MEN1GAAKMT2ASMN1; SMN2TRPM8 | |
| SCHEMBL14616914 | 0.70 | ALDH1A1 (0.48) | MEN1GAAKMT2ACYP3A4CYP2C19 | |
| SCHEMBL7876820 | 0.70 | GAA (0.38) | MEN1GAAKMT2ASMN1; SMN2TRPM8 | |
| SCHEMBL22540087 | 0.68 | CYP3A4 (0.35) | MEN1GAAKMT2ACHRNB2CHRNB4 | |
| SCHEMBL6742890 | 0.67 | CPB2 (0.42) | MEN1GAAKMT2ASMN1; SMN2CYP3A4 | |
| SCHEMBL10398577 | 0.67 | ALDH1A1 (0.44) | MEN1GAAKMT2ASMN1; SMN2CYP3A4 | |
| SCHEMBL7879761 | 0.67 | GABRR1 (0.54) | MEN1GAAKMT2ACYP3A4CYP2C19 | |
| SCHEMBL11668486 | 0.67 | ALDH1A1 (0.40) | CHRM1MEN1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL9521411 | 0.67 | ALDH1A1 (0.44) | MEN1GAAKMT2ASMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637731-A | CHOLINERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-10 | — | — | US | disclosed |
| US-5550257-A | TREATING CENTRAL CHOLINERGIC DYSFUNCTION | AMERICAN CYANAMID COMPANY (US) | 1996-08-27 | — | — | US | disclosed |
| US-5451685-A | MANUFACTURING PHARMACEUTICALS | AMERICAN CYANAMID COMPANY (US) | 1995-09-19 | — | — | US | disclosed |
| US-5356885-A | Cholinergic agents; administering for treatment of diseases of the central nervous system | AMERICAN CYANAMID COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| EP-0510333-A1 | Substituted oxotremorine derivatives | AMERICAN CYANAMID COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |