Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8848238 | 0.80 | ALDH1A1 (0.33) | ALDH1A1HSD17B10LMNA | |
| SCHEMBL333135 | 0.77 | PKM (0.47) | ALDH1A1HSD17B10PKMATM | |
| SCHEMBL2424206 | 0.71 | TSHR (0.36) | ALDH1A1SOAT1HSD17B10LMNA | |
| SCHEMBL8847386 | 0.69 | ALDH1A1 (0.36) | ALDH1A1SOAT1 | |
| Ethyne SCHEMBL167200 | 0.67 | ALDH1A1 (0.87) | ALDH1A1SOAT1HSD17B10PKMLMNA | |
| SCHEMBL1332089 | 0.67 | — | — | |
| SCHEMBL1958756 | 0.67 | ALDH1A1 (1.00) | ALDH1A1SOAT1HSD17B10PKMLMNA | |
| SCHEMBL3673 | 0.67 | — | — | |
| SCHEMBL499558 | 0.66 | — | — | |
| Charcoal, Activated SCHEMBL1901032 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| EP-0581166-A1 | Benzimidazoles, process for their preparation and their use as angiotensin-II antagonists | Dr. Karl Thomae GmbH (DE) | 1994-02-02 | — | — | EP | disclosed |